Preheat oven to 350°F. Line 24 muffin tins with liners and set aside.
In a medium bowl, beat cream cheese with a hand mixer until smooth. Add granulated sugar, egg, and vanilla and beat on medium speed until smooth and combined. Set aside.
In the bowl of your stand mixer, combine cake mix, pudding mix, milk, vegetable oil, and eggs. Beat on low speed for 30 seconds. Increase speed to medium and beat for two more minutes.
Fill muffin tins half-full with batter.
Top each with a spoonful of cheesecake filling – each tin should be about 2/3 full when complete.
Bake for about 15 – 20 minutes or until cupcakes spring back when lightly touched in the center. Let cool for a few minutes in the pan before removing to wire racks to cool completely.