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Delicious Oven Cooked Barbecue Brisket

This Delicious Oven Cooked Barbecue Brisket brings all the deep, smoky flavors of traditional outdoor BBQ straight to your kitchen—no smoker required. Made with a simple rub, liquid smoke, Worcestershire sauce, and your favorite barbecue sauce, this brisket stays incredibly juicy, tender, and richly seasoned from edge to center. Slow-cooked to perfection, it’s the ideal recipe for anyone craving authentic smoky beef without the fuss of outdoor grilling or hours spent tending a smoker.
Prep Time10 minutes
Cook Time6 hours
Marinating Time1 day
Total Time1 day 6 hours 10 minutes
Servings: 10

Ingredients

  • 5 –6 pounds brisket
  • 1 teaspoon celery salt
  • 1 teaspoon garlic powder
  • 1 teaspoon onion salt
  • 2 ounces liquid smoke
  • 1 ounce Worcestershire sauce
  • 1 cup prepared barbecue sauce your choice

Instructions

  • Whisk celery salt, garlic powder, and onion salt in a small bowl.
  • Season both sides of the brisket with the spice mixture.
  • Place brisket in a foil-lined baking pan large enough to fully enclose it.
  • Pour liquid smoke and Worcestershire sauce over the meat.
  • Lift brisket slightly so the liquid coats underneath as well.
  • Seal foil tightly around the brisket.
  • Refrigerate and marinate overnight.
  • Remove brisket from refrigerator and let stand 30 minutes to reach room temperature.
  • Preheat oven to 275°F (135°C).
  • Bake brisket sealed in foil for 5 hours.
  • Open foil and pour 1 cup barbecue sauce over the meat.
  • Bake uncovered for an additional 60 minutes.
  • Let cool slightly before slicing.
  • Slice thinly and serve warm.

Notes

Ingredient Substitutions

  • Swap beef brisket with chuck roast for a budget-friendly option.
  • Use onion powder instead of onion salt if you want less sodium.
  • Choose smoky, spicy, or sweet BBQ sauce depending on preference.

Make-Ahead & Storage

  • Brisket tastes even better the next day.
  • Store sliced brisket with its juices up to 4 days in the fridge.
  • Freeze up to 3 months; thaw overnight and reheat covered.

Serving Variations

  • Serve on brioche buns for BBQ sandwiches.
  • Pair with mac and cheese, baked beans, or roasted corn.
  • Shred leftovers and use in tacos or quesadillas.

Avoid Common Mistakes

  • Don’t skip the overnight marinade—it builds flavor and tenderness.
  • Resist raising the oven temperature; low and slow is essential.
  • Slice brisket thinly against the grain for tenderness.