Preheat oven to 350 °F. Grease a 9×13 baking dish lightly.
Make the beef filling: In a skillet, brown ground beef over medium heat; drain excess fat if needed. Stir in ketchup, brown sugar, mustard, garlic powder, and Worcestershire sauce if using. Simmer until thickened, ~5 minutes. Remove from heat.
Prepare cornbread batter: In a mixing bowl, whisk cornmeal, flour, baking powder, salt. In another bowl, combine honey, milk, and eggs. Stir wet into dry ingredients until just combined; fold in half the cheddar and ½ cup corn.
Par‑bake base: Spread about two‑thirds of batter into the prepared dish. Bake 15 minutes—cornbread will be nearly set.
Layer and assemble: Sprinkle the remaining ½ cup corn over par‑baked base. Spoon beef mixture evenly. Dollop remaining batter over the top, spreading gently. Sprinkle with remaining cheddar.
Bake until golden: Return to oven for 20–25 minutes, until cornbread is golden, cheese is melted, and center is cooked through.
Rest: Let the casserole rest 5 minutes before slicing and serving.